Use the Back button in your browser to see the other results of your search or to select another record.

Detailed Search Results

Effectiveness of energy conservation management on fatigue and participation in multiple sclerosis: a randomized controlled trial
Blikman LJM, van Meeteren J, Twisk JWR, de Laat FAJ, de Groot V, Beckerman H, Stam HJ, Bussmann JBJ, Malekzadeh A, van den Akker LE, Looijmans M, Sanches SA, Dekker J, Collette EH, van Oosten BW, Teunissen CE, Blankenstein MA, Eijssen I, Rietberg M, Heine M, Verschuren O, Kwakkel G, Visser-Meily JMA, van de Port IGL, Lindeman E, Hintzen RQ, Hacking HGA, Hoogervorst EL, Frequin S, Knoop H, de Jong BA, Bleijenberg G, Verhulsdonck MC, van Munster ETL, Oosterwijk CJ, Aarts GJ, on behalf of TREFAMS-ACE study group
Multiple Sclerosis Journal 2017 Oct;23(11):1527-1541
clinical trial
8/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Fatigue is a frequently reported and disabling symptom in multiple sclerosis (MS). OBJECTIVE: To investigate the effectiveness of an individual energy conservation management (ECM) intervention on fatigue and participation in persons with primary MS-related fatigue. METHODS: A total of 86 severely fatigued and ambulatory adults with a definite diagnosis of MS were randomized in a single-blind, two-parallel-arm randomized clinical trial to the ECM group or the information-only control group in outpatient rehabilitation departments. Blinded assessments were carried out at baseline and at 8, 16, 26 and 52 weeks after randomization. Primary outcomes were fatigue (fatigue subscale of Checklist Individual Strength -- CIS20r) and participation (Impact on Participation and Autonomy scale -- IPA). RESULTS: Modified intention-to-treat analysis was based on 76 randomized patients (ECM n = 36; MS nurse n = 40). No significant ECM effects were found for fatigue (overall difference CIS20r between the groups -0.81; 95% confidence interval (CI) -3.71 to 2.11) or for four out of five IPA domains. An overall unfavourable effect was found in the ECM group for the IPA domain social relations (difference between the groups 0.19; 95% CI 0.03 to 0.35). CONCLUSION: The individual ECM format used in this study did not reduce MS-related fatigue and restrictions in participation more than an information-only control condition.

Full text (sometimes free) may be available at these link(s):      help