BACKGROUND: Overweight and metabolic problems now add to the burden of illness in patients with inflammatory bowel disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with inflammatory bowel disease. METHODS: A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by dual energy x-ray absorptiometry was performed. Patients in clinical remission and physically inactive with a mean age of 25 +/- 6.5 years and body mass index of 28.9 +/- 3.8 were recruited from a dedicated inflammatory bowel disease clinic. Serum cytokines were quantified, and microbiota assessed using metagenomic sequencing. RESULTS: Improved physical fitness was demonstrated in the exercise group by increases in median estimated VO2 (baseline 43.41mls/kg/min; post-intervention 46.01mls/kg/min; p = 0.03). Improvement in body composition was achieved by the intervention group (n = 13) with a median decrease of 2.1% body fat compared with a non-exercising group (n = 7) (0.1% increase; p = 0.022). Lean tissue mass increased by a median of 1.59 kg and fat mass decreased by a median of 1.52 kg in the exercising group. No patients experienced a deterioration in disease activity scores during the exercise intervention. No clinically significant alterations in the alpha- and beta-diversity of gut microbiota and associated metabolic pathways were evident. CONCLUSIONS: Moderate-intensity combined aerobic and resistance training is safe in physically unfit patients with quiescent inflammatory bowel disease and can quickly achieve favourable body compositional changes without adverse effects. TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov trial number NCT02463916.

Full text (sometimes free) may be available at these link(s):      help

• PubMed Central
• DOI
• PubMed
• PDF locator
• publisher