Exercise is recognized as a frontline therapy for the prevention and treatment of type 2 diabetes (T2D) but the optimal type of exercise is not yet determined. We compared the effects of high-intensity interval training (HIIT) with moderate-intensity continuous training (MICT) for improvement of continuous glucose monitoring (CGM)-derived markers of glycaemic variability, and biomarkers of endothelial cell damage (CD31+ and CD62+ endothelial microparticles (EMPs)) within a population at elevated risk of developing T2D. Fifteen inactive overweight or obese women were randomized to 2 weeks (10-sessions) of progressive HIIT (n = 8, 4 to 10X 1-min at approximately 90% peak heart rate, 1-min rest periods) or MICT (n = 7, 20 to 50 min of continuous activity at approximately 65% peak heart rate). Prior and three days post-training, fasting blood samples were collected. Both HIIT and MICT improved glycaemic variability as measured by CGM standard deviation (HIIT 0.82 +/- 0.39 versus 0.72 +/- 0.33 mmol/L; MICT: 0.82 +/- 0.19 versus 0.62 +/- 0.16 mmol/L, pre versus post) and mean amplitude of glycaemic excursions (MAGE; HIIT 1.98 +/- 0.81 versus 1.41 +/- 0.90; MICT; 1.98 +/- 0.43 versus 1.65 +/- 0.48, pre versus post) with no difference between groups. CD62+ EMPs were lower following HIIT (187.7 +/- 65 versus 174.9 +/- 55, pre versus post) and MICT (170 +/- 60 versus 160.3 +/- 59, pre versus post) with no difference between groups. There was no change in 24-h mean glucose or CD31+ EMPs. Two weeks of both HIIT or MICT similarly decreased glycaemic variability and CD62+ EMPs in overweight/obese women at elevated risk of T2D.

Full text (sometimes free) may be available at these link(s):      help

• DOI
• PubMed
• PDF locator
• publisher