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Moderate- to high-intensity exercise does not modify cortical beta-amyloid in Alzheimer's disease [with consumer summary]
Frederiksen KS, Madsen K, Andersen BB, Beyer N, Garde E, Hogh P, Waldemar G, Hasselbalch SG, Law I
Alzheimer's & Dementia 2019;5(1):208-215
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

INTRODUCTION: Animal models of Alzheimer's disease show that exercise may modify beta-amyloid (Abeta) deposition. We examined the effect of a 16-week exercise intervention on cortical Abeta in patients with mild-to-moderate Alzheimer's disease. METHODS: Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11-Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Abeta, and quantified using standardized uptake value rations (SUVRs). RESULTS: The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini-Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. DISCUSSIONS: The present findings do not support an effect of exercise on Abeta. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.

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