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| Effects of exercise training on heart rate variability in Chagas heart disease |
| Nascimento BR, Lima MM, Nunes MCP, Alencar MC, Costa HS, Pinto Filho MM, Cota VE, Rocha MO, Ribeiro AL |
| Arquivos Brasileiros de Cardiologia 2014 Sep;103(3):201-208 |
| clinical trial |
| 5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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BACKGROUND: Heart rate variability (HRV) is a marker of autonomic dysfunction severity. The effects of physical training on HRV indexes in Chagas heart disease (CHD) are not well established. OBJECTIVE: To evaluate the changes in HRV indexes in response to physical training in CHD. METHODS: Patients with CHD and left ventricular (LV) dysfunction, physically inactive, were randomized either to the intervention (IG N = 18) or control group (CG N = 19). The IG participated in a 12-week exercise program consisting of 3 sessions/week. RESULTS: Mean age was 49.5 +/- 8 years, 59% males, mean LVEF was 36.3 +/- 7.8%. Baseline HRV indexes were similar between groups. From baseline to follow-up, total power (TP): 1,653 (IQ 625 to 3,418) to 2,794 (1,617 to 4,452) ms, p = 0.02) and very low frequency power: 586 (290 to 1,565) to 815 (610 to 1,425) ms, p = 0.047) increased in the IG, but not in the CG. The delta (post minus pre) HRV indexes were similar: SDNN 11.5 +/- 30.0 versus 3.7 +/- 25.1 ms. p = 0.10; rMSSD 2 (6 to 17) versus 1 (21 to 9) ms. p = 0.43; TP 943 (731 to 3,130) versus 1780 (921 to 2743) Hz. p = 0.46; low frequency power (LFP) 1.0 (150 to 197) versus 60 (111 to 146) Hz. p = 0.85; except for high frequency power, which tended to increase in the IG 42 (133 to 92) versus 79 (61 to 328) Hz. p = 0.08). CONCLUSION: In the studied population, the variation of HRV indexes was similar between the active and inactive groups. Clinical improvement with physical activity seems to be independent from autonomic dysfunction markers in CHD.
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