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Effects of exercise on the cognition of older women treated with lovastatin
Molina-Sotomayor E, Arreguin-Moreno R, Rodriguez-Rodriguez F, Pradas F, Leon JA, Gonzalez-Jurado JA
Biomedica 2018 Dec;38(4):496-506
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

INTRODUCTION: The deterioration of cognition is highly predominant in older adults. OBJECTIVE: The aim of this study was to analyze the effects of a walking program on the cognition and blood concentration of lipids in women over 60 years of age who were being treated with lovastatin. MATERIALS AND METHODS: Participants were distributed in two groups: An exercise group (EG n = 45) with aerobic training and an inactive sedentary group (SG n = 22). The cognitive state of the subjects was assessed through the Spanish Mini-Cog Test version of the MMSE; lipoproteins were quantified using a lipid profile test, and the cardiorespiratory fitness was measured using the six-minute walking test (6MWT). RESULTS: EG showed a significant increase (p < 0.05) in cardiorespiratory fitness and in HDL-C concentrations. Furthermore, the results from the cognition tests showed a large effect size in spatial orientation and in and calculation. The decrease in LDL-C was not significant (p > 0.05). CONCLUSION: A controlled and progressive walking program for older women treated with Lovastatin may induce a boost of brain activity linked to HDL-C, which could delay cognitive impairment.

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