INTRODUCTION: Resistin is an adipocyte-specific hormone secreted from adipose tissue which plays a significant role in the energy homeostasis and regulation of energy metabolism. The purpose of this study was to examine the effects of eight weeks of aerobic training on the resistin levels and insulin resistance in sedentary middle-aged women. METHOD(S): In this quasi-experimental research, 20 sedentary women were randomly selected and assigned to two groups: experimental group, n = 10, aged 47.70 +/- 5.35; and control, n = 10, age 41.30 +/- 3.02, respectively. The participants in the training group performed an exercise protocol three times per week with the goal of 55 to 65% of maximum heart rate. Before and after the completion, the resistin, insulin, glucose and insulin resistance levels were measured after 12 h of overnight fasting. Data were analyzed before and after the intervention by t-test. The significant level was defined as p <= 0.05. RESULT(S): Aerobic training in compared with the control group showed significant effect in decreasing resistin levels (p = 0.012), BMI (p = 0.01), insulin resistance (p = 0.01), and increasing VO2max (p = 0.004). CONCLUSION(S): It appears that eight weeks of aerobic training significantly changes the level of resistin and the insulin resistance index in sedentary middle-aged women. Plasma resistin may be associated with insulin resistance in sedentary women. In general, according to the results, we may say that an eight-week aerobic training with a significant reduction in plasma resistin has a preventive effect as a new and effective training method on insulin resistance in middle-aged sedentary women.

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