The effects of moderate intensity treadmill exercise training (MI), resistance training (RT), and combined treadmill plus resistance training (CT) on markers of male reproductive function including seminal markers of oxidative stress and inflammation, and semen quality and sperm DNA integrity were evaluated in healthy human subjects. A total of 376 healthy sedentary male volunteers (aged 25 to 40) were screened and 282 were randomized into 4 treatment groups: MI (n = 71), RT (n = 71), CT (n = 71), and nonexercise (NON-EX, n = 70) groups for an experimental period of 24 weeks. After the intervention, compared with the NON-EX group, all 3 MI, RT, and CT exercise modalities showed significantly reduced body mass, fat percent, waist circumference, reactive oxygen species, interleukin (IL)-1beta, IL-6, IL-8 and tumor necrosis factor-a and improved maximal oxygen uptake (VO2max), progressive motility, sperm morphology, sperm concentration and sperm DNA integrity, as indicated by a decrease of percentage of terminal deoxynucleotidyl transferase-mediated fluorescein-dUTP nick end labeling-positive sperm cells (p <= 0.05). Body mass index, semen volume, number of spermatozoa, superoxide dismutase, catalase, total antioxidant capacity, malondialdehyde, and 8-isoprostane improved significantly in the MI and CT groups (p <= 0.05) but not significantly in the RT group (p > 0.05). In summary, all 3 MI, RT, and CT interventions attenuate seminal markers of inflammation and oxidative stress and improve body composition, semen quality parameters, and sperm DNA integrity in the studied population. In respect to all the aspects studied, those men who took part in MI intervention had the best results. Considering the seminological parameters, however, CT had a synergistic effect and was superior over the other interventions used.

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