PURPOSE: The purpose of this study was to examine the effects of a 12-wk in-home self-monitored physical activity (PA) program targeting a combination of lifestyle PA program on changes in endothelial reactivity, arterial stiffness, sedentary behaviors, and upright and stepping activities in individuals with asymptomatic peripheral arterial disease (APAD). METHODS: Participants (n = 38) with APAD (ages 52 to 87 yr) were randomized to attention control (AC) or a PA sedentary reduction (PASR) group using an interactive online 3-month program focusing on increasing lifestyle PA and decreasing sedentary behaviors. The ActivPal PA monitor was used to measure postural and stepping parameters. Endothelial reactivity (peripheral arterial tone-reactive hyperemia index (PAT-RHI)) and augmentation index (AIx) were measured using the EndoPAT system at baseline and 3 months. RESULTS: The PASR group significantly decreased daily sit/lie hours (-0.80 +/- 0.87 versus 0.18 +/- 0.77 p = 0.001), increased sit-to-stand transitions per day (7.1 +/- 10.5 versus -1.4 +/- 5.71, p < 0.001), and increased daily step counts (2,814 +/- 1,753 versus 742 +/- 1,321, p < 0.001). The PASR group also increased steps per day accumulated within specific cadence bands 61 to 80 steps per minute (1,252 +/- 447 versus 177 +/- 359, p < 0.001), 81 to 100 steps per minute band (919 +/- 511 versus -98 +/- 697, p < 0.001), and within the 101 to 120 steps per minute band (415 +/- 625 versus -327 +/- 467, p < 0.001) versus the AC group. PAT-RHI significantly increased in the PASR group (0.179 +/- 0.180 versus 0.0.044 +/- 0.101, p = 0.019), whereas no significant changes were observed in PAT-AIx. CONCLUSIONS: Modest improvements in microvascular reactivity, PA, sedentary behavior, but not arterial stiffness were demonstrated after a 12-wk intervention targeting sedentary behavior reduction and increased lifestyle PA in individuals with APAD.

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