BACKGROUND: Numerous researchers have worked to develop treatments for obesity; however, the prevalence of obesity continues to increase in many countries. Moreover, the effects of physical activity and exercise on obesity remain unclear. Therefore, it is necessary to perform a systematic review and meta-analysis to assess the relationship between exercise and obesity using mediator variables such as the mode of exercise. METHODS: Our review focuses on research tracking the effects of exercise on obesity conducted from 2007 to 2016 and available in any of three databases: Embase, PubMed, and EBSCO Academic Search Premier. The keywords used in the search were "exercise and obesity" and "exercise and obese." RESULTS: The average size of the effects that exercise interventions have on body mass index (standardized mean difference (SMD) 0.533), waist circumference (SMD 0.666), total cholesterol (SMD 0.721), and triglyceride (TG; SMD 0.603) were medium or larger. Exercise had greater effects on the outward appearance of obesity (body mass index, waist circumference) than on its practical factors (weight, % body fat). The effect of exercise on TG (SMD 0.603) was larger than that on low-density lipoprotein (SMD 0.406) and high-density lipoprotein (SMD -0.222). Exercise duration (weeks of exercise) and intensity correlate better than exercise time (minutes per week) with a large and consistent improvement in adult obesity. CONCLUSION: We suggest that individuals with obesity should exercise consistently to achieve significant improvements in their health.

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