OBJECTIVES: To compare the effects of continuous and pulsed therapeutic ultrasound combined with strengthening exercises. DESIGN: This is a double-blind randomized controlled trial. SETTING: Pontifical Catholic University. SUBJECTS: One hundred participants with grade 2 to 4 knee osteoarthritis and both genders were involved. INTERVENTION: Participants were randomized into five groups: group I (n = 20; in the first month, continuous ultrasound was applied), group II (n = 20; in the first month, pulsed ultrasound was applied), group III (n = 20; in the first and second months, continuous ultrasound was applied), group IV (n = 20; in the first and second months, pulsed ultrasound was applied) and group V (n = 20; patients received only exercise sessions for eight weeks). All patients in the groups that received ultrasound application performed exercises in the second month of treatment. The sessions occurred three times a week. MAIN MEASURES: Pain was assessed using the visual analogical scale, functionality was assessed using the Lequesne questionnaire, range of motion was assessed using a universal goniometer, muscular strength was assessed using a dynamometer, mobility was assessed using the Timed Up and Go test and 8-meter walk test and the activity level was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. RESULTS: Statistically significant differences (p < 0.05) were presented by group III in the variables pain during activities of daily living (ADLs) 5.89 (2.18), mobility assessed by 8-meter test 2.68 (2.56), in pain 10.65 (4.40), function 25.50 (10.87) and total 38.65 (15.29) of WOMAC and functionality 9.10 (5.15). CONCLUSION: Prolonged applications of continuous ultrasound combined with exercises are effective in providing pain, mobility, functionality and activity in subjects with knee osteoarthritis.

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