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| The effect of aerobic exercise on white matter hyperintensity progression may vary by sex |
| Dao E, Barha CK, Best JR, Hsiung G-Y, Tam R, Liu-Ambrose T |
| Canadian Journal on Aging 2019 Jun;38(2):236-244 |
| clinical trial |
| 5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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ABSTRACT: This study explored the efficacy of aerobic training (AT) in mitigating white matter hyperintensity (WMH) progression and whether these changes are sex dependent. This was an exploratory analysis of a randomized controlled trial assessing the effect of AT on cognition in people with vascular cognitive impairment. Participants were randomized to a 6 month AT or usual care (control (CON)) group. A subset completed magnetic resonance imaging to quantify WMH volume. Using an analysis of covariance model, we found a significant sex x group interaction (p = 0.03). Over the 6 month study, AT females demonstrated greater WMH progression than CON females (p = 0.05). Among males, there was no significant between-group difference (p = 0.31). Within the AT group, males demonstrated significantly less WMH progression than females (p = 0.01) at 6 months. Therefore, the effects of AT on WMH progression may vary by sex; that is, AT may curtail WMH progression in males but not females.
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