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Randomized comparison of functional electric stimulation in posturally corrected position and motor program activating therapy: treating foot drop in people with multiple sclerosis [with consumer summary]
Prokopiusova T, Pavlikova M, Markova M, Rasova K
European Journal of Physical and Rehabilitation Medicine 2020 Aug;56(4):394-402
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Functional electric stimulation (FES) is recommended for foot drop in multiple sclerosis, although little is known about its therapeutic effect. AIM: To evaluate a therapeutic effect immediately and two months after program termination (persistent and delayed effect) of a new approach using FES in combination with correcting the patients' postural system. More specifically, we evaluate the effects of this approach on the patients' clinical functions and compared it with individual physiotherapy. DESIGN: Parallel randomised blind trial. SETTING: 2-month long treatments, functional electric stimulation in posturally corrected position (group 1) and neuroproprioceptive facilitation and inhibition physiotherapy called motor program activating therapy (group 2). POPULATION: 44 subjects with multiple sclerosis. METHODS: Primary outcomes: gait (the 2-Minute Walk Test; Timed 25-Foot Walk test; Multiple Sclerosis Walking Scale-12) and balance (by eg, Berg Balance Scale, BBS; The Activities-Specific Balance Confidence Scale, ABC; Timed Up and Go Test, TUG). Secondary outcome: mobility, cognition, fatigue and subjects' perceptions (eg, Multiple Sclerosis Impact Scale, MSIS; Euroqol-5 dimensions-5 levels, EQ-5D-5L). RESULTS: Group 1 showed immediate therapeutic effect in BBS (p = 0.008), ABC (p = 0.04) and EQ-5D-5L (self-care p = 0.019, mobility p = 0.005). The improvement in EQ-5D-5L persisted and in TUG-cognitive we documented a delayed effect (p = 0.005). Group 2 showed an immediate improvement in BBS (p = 0.025), MSIS (p = 0.043) and several aspects of daily life (the effect on health today was significantly higher than in group 1, significant difference between groups p = 0.038). CONCLUSIONS: FES in the posturally corrected position has an immediate therapeutic effect on balance and patients' perceptions comparable to motor program activating therapy, and higher persistent and even delayed therapeutic effect.

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