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Effectiveness of high-intensity interval training versus moderate-intensity continuous training in patients with fibromyalgia: a pilot randomized controlled trial
Atan T, Karavelioglu Y
Archives of Physical Medicine and Rehabilitation 2020 Nov;101(11):1865-1876
clinical trial
7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) combined with strengthening and stretching exercises in patients with fibromyalgia. DESIGN: Interventional, single-blinded, randomized-controlled trial. SETTING: Outpatient rehabilitation center. PARTICIPANTS: Sixty women diagnosed with fibromyalgia were randomized to HIIT, MICT and control groups. INTERVENTIONS: HIIT included a 5-min warm-up at 50% of peak-HR, four cycles of 4-min at 80 to 95% of peak-HR followed by 3-min recovery intervals at 70% of peak-HR. MICT consisted of 45-min at 65 to 70% of peak-HR. Each aerobic training session was followed by standardized strengthening and stretching exercises. The programs performed using cycle-ergometers 5-sessions per-week for 6-weeks. The control group did not participate in any supervised exercise sessions. MAIN OUTCOME MEASURES: The primary outcome measure was the Fibromyalgia Impact Questionnaire (FIQ). The secondary outcome measures were visual analogic scale for pain, Short Form Health Survey-36 (SF-36), cardiopulmonary exercise test (CPET) and body composition parameters. RESULTS: Fifty-five participants completed the study. There was no significant difference in FIQ between HIIT versus MICT (1.03; 95% confidence interval (CI) -9.67 to 11.75) after treatment. Group-time interactions were significant for the FIQ between interventions and control (HIIT versus control -16.20; 95% CI -27.23 to -5.13 and MICT versus control -17.24; 95% CI -28.27 to -6.22) (all p < 0.001). There were significant group-time interactions for the pain, SF-36 and CPET parameters between treatments and control (all p < 0.05). Body-weight, fat-percentage, fat-mass and body mass index improved significantly (all p < 0.05) only in MICT group after treatment. CONCLUSIONS: The HIIT plus strengthening and stretching exercises and MICT plus strengthening and stretching exercises interventions showed significant improvements for the impact of fibromyalgia, pain degree, functional capacity and quality of life compared to the control group. HIIT was not superior to MICT. Furthermore, body composition parameters were improved significantly only for the MICT.

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