Despite the high incidence of patellofemoral pain syndrome (PFPS), few studies show the effects of radiofrequency on pain and functionality in these patients. For this reason, the aim of this study was to determine the efficacy of monopolar dielectric diathermy by emission of radiofrequency (MDR) in dynamic applications aimed at treating pain and improving function in patients with PFPS. For this purpose, a single-blind randomized clinical trial was conducted. Eighty-four participants with PFPS were evenly divided into an experimental group (EG) and a control group (CG). All subjects receive 10 min of daily home exercises along 3 weeks, and in addition, the subjects of the EG received 10 sessions based on the dynamic application of MDR. Variables measured included visual analogue scale (VAS), DN4 questionnaire, Lower Extremity Functionality Scale (LEFS), Kujala Scale, range of movement (ROM) in knee flexion and extension and drug intake. The EG showed a statistically significant reduction in pain (VAS 4.8 (5.5 to 4.1) (p < 0.001); DN4 3.8 (4.4 to 3.2) (p < 0.001)), and an increase in functionality (LEFS 16 (19 to 13) (p < 0.001); Kujala 19 (23 to 14) (p < 0.001)) and in ROM (flexion 18 (21 to 16) (p < 0.001)). No statistically significant changes in drug intake were found. Based on this data, the dynamic application of MDR seems effective in reducing pain and increasing functionality and flexion in patients with PFPS. Diathermy by emission of radiofrequency could be recommended as complement or main therapy in the treatment of PFPS.

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