OBJECTIVE: To assess the effect of manual lymph drainage (MLD) on pain in Japanese patients up to 10 days after a total knee arthroplasty (TKA). METHODS: This study was a randomized controlled trial performed at a university medical center. Patients who underwent unilateral TKA and received once daily MLD for 20 minutes prior to standard physical therapy up to 10 days after TKA were investigated. Pain at rest, knee extension muscle contraction, and maximum load were assessed using the visual analog scale (mm) before surgery, after drain removal, and after the fifth MLD. As secondary outcomes, the circumference, range of motion, muscle strength, walking speed, and walking rate were evaluated. RESULT: Forty-one patients aged 45 to 85 participated in this study, 21 of whom were assigned to the intervention (MLD group) and 20 who were not (control group). Ten days after TKA, no significant difference was evident between the MLD and control groups for resting pain (4.5 mm (1.6 to 10.8) versus 7.0 mm (1.8 to 25.5), respectively, p = 0.17), pain during knee extension muscle contraction (12.3 mm (4.5 to 24.8) versus 20.8 mm (6.4 to 31.8), p = 0.41), and pain at maximum load (13.0 mm (8.3 to 39.8) versus 16.0 mm (4.6 to 32.5), p = 0.73). There were no significant differences between groups in terms of secondary outcomes. CONCLUSION: This study shows that MLD up to 10 days after TKA does not affect pain.

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