BACKGROUND: Hypertension induces cardiac hypertrophy. Oxidative stress plays an important role in the pathogenesis of hypertension induced cardiac hypertrophy. Exercise and quercetin (as activators of Sirtuins) reduce oxidative stress. The aim of this study was to investigate the effect of high-intensity interval training (HIIT) with quercetin supplement on oxidative stress and level of concentric pathologic hypertrophy in patients with hypertension and coronary heart disease after angioplasty. METHOD(S): The present study was conducted experimentally randomized, placebo-controlled and double-blind on 24 men with hypertension and coronary heart disease after angioplasty aged 40 to 60 since years May to August 2019 at the Exercise Physiology department of Sport Sciences Faculty, Shahid Rajaee Teacher Training University, Tehran, Iran. The subjects were randomly divided into two groups of HIIT+quercetin (n = 12) and HIIT+placebo (n = 12) and were followed during 8 weeks of high-intensity interval training (30 seconds of activity and 30 seconds of rest) and quercetin consumption (250 mgr of quercetin supplement or placebo pills daily). Echocardiography was used to investigate morphological factors such as posterior wall dimension (PWd) and left ventricular end diastolic diameter (LVEDd). Plasma total antioxidant capacity (TAC) and malondialdehyde (MDA) were measured by colorimetric method. RESULT(S): The results showed that MDA and The relative wall thickness (RWT) decreased after 8 weeks in HIIT+supplement and HIIT+placebo groups and TAC level and LVEDd increased significantly (p < 0.05). PWd decreased significantly only in the exercise+supplement group (p < 0.05). No significant difference between groups in any other variables was detected (p > 0.05). CONCLUSION(S): Eight weeks of high-intensity interval training alone or with quercetin by reducing oxidative stress, increasing total antioxidant capacity (TAC) and reducing malondialdehyde (MDA) reduces level of concentric pathologic hypertrophy in men with hypertension and coronary heart disease after angioplasty. So that high-intensity interval training with quercetin supplementation has relatively more effects.

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