OBJECTIVES: To evaluate the effects of structured exercise regime on glycosylated hemoglobin and C reactive protein in patients with gestational diabetes mellitus. METHODS: This two arm parallel randomized controlled trial was conducted at Fauji Foundation Hospital, Rawalpindi from November 2018 till December 2019 on the 54 diagnosed gestational diabetes mellitus patients (dropped out 4, analyzed 50) with age 20 to 40 years and gestational age from 20 to 36 weeks. Selection was done via convenient sampling technique and randomized into two groups (N = 25) by sealed envelope method. Structured exercise regime group received combination of moderate intensity aerobics, stabilization and pelvic floor muscles exercises twice a week for 5 weeks (40 min per session) along with dietary and medical interventions while control group received only medical and dietary interventions with postural education. Demographics, glycosylated hemoglobin and C reactive protein were recorded at baseline then after 5 weeks of intervention. Analysis was done by SPSS 20. RESULTS: Mean age was 35.92 +/- 5.24 years in control group while 34.36 +/- 5.21 years in interventional group. Between group analysis for HbA1c showed no significant difference at base line (p > 0.05) but showed significant difference (p < 0.05) after five weeks' interventions. Similarly, for C reactive protein both groups showed no significant difference (p > 0.05) at baseline but after five weeks of interventions showed significant difference (p < 0.05). CONCLUSION: Structured exercise regime helps in reducing values of glycosylated hemoglobin and C reactive protein in patients with gestational diabetes mellitus. TRIAL REGISTRATION: ClinicalTrials.gov NCT04146740.

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