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| The effects of acupuncture at different intervention time points on nausea and vomiting caused by cisplatin chemotherapy in patients with lung cancer |
| Cheng P, Wang X |
| International Journal of Clinical and Experimental Medicine 2020;13(10):7965-7971 |
| clinical trial |
| 7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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OBJECTIVE: To explore the effects of the timing of acupuncture intervention on nausea and vomiting (CINV) caused by cisplatin in patients with lung cancer. METHOD(S): A total of 105 patients with lung cancer were randomly divided into a pre-chemotherapy acupuncture group (PRG) who receive acupuncture 30 minutes before chemo-therapy, a post-chemotherapy acupuncture group (POG) who receive acupuncture 30 minutes after chemotherapy, and a control group who were not given acupuncture intervention. Complete remission (CR) rate and the response rate of chemotherapy-related nausea and vomiting after acupuncture intervention at different times, frequency of nausea and vomiting and their total score on INVR scale were compared. RESULT(S): There were statistically significant differences in the response and CR rates between the PRG, POG and control group 3 days before chemotherapy (all p < 0.05). In terms of INVR scores, no statistical difference between the POG and control group on the first day of chemotherapy, but the PRG differed significantly from the POG and control group (p < 0.05). On the 2nd to 7th day of chemotherapy, the difference between the three groups was statistically significant (p < 0.05). CONCLUSION(S): Acupuncture before chemotherapy can effectively reduce the frequency of nausea and vomiting associated with cisplatin chemotherapy in lung cancer patients, improve the effectiveness of CINV treatment, and can be widely promoted in clinic.
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