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The impact of exercise on serum irisin, osteocalcin, and adiponectin levels and on glycolipid metabolism in patients with type 2 diabetes
Yang D, Li Y, Fan X, Liang H, Han R
International Journal of Clinical and Experimental Medicine 2020;13(10):7816-7824
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: This study aimed to investigate the impact of a 12-week moderate-intensity exercise intervention on the serum Irisin, osteocalcin (OC), and adiponectin (ADP) levels and their relationships with glycolipid metabolism, islet beta-cell function, and insulin resistance status in patients with type 2 diabetes (T2DM). METHOD(S): 60 patients with T2DM were randomly assigned to an exercise group (EG, n = 30) and a control group (CG, n = 30). 20 age-matched healthy individuals were recruited for a normal control group (NCG). The T2DM EG underwent a regular exercise intervention for 12 weeks. Their pre-and post-training anthropometric and biochemical indica-tors and their serum irisin, OC, and ADP levels were determined. RESULT(S): the baseline irisin and ADP levels in the T2DM groups were lower than they were in the NCG (p < 0.05). The post-training irisin and ADP levels in the T2DM EG were significantly increased (p < 0.05), and there were no changes in the OC levels (p > 0.05). The BMI, HbA1C, FPG, 2 h PBG, HOMA2-%B, and HOMA2-IR levels were significantly improved compared with their pre-training levels and with the T2DM CG's levels (p < 0.05). A correlation analysis showed that the serum OC levels were negatively correlated with the FPG, 2 h PBG, and HOMA2-IR levels in the T2DM patients and positively correlated with the serum ADP and irisin levels (p < 0.05). The serum irisin level was negatively correlated with the 2 h PBG level and positively correlated with the serum ADP level (p < 0.05). The OC change rate was positively correlated with the FCP and HOMA2-IR change rates (p < 0.05). The irisin change rate was negatively correlated with the FPG and HOMA2-IR change rates and positively correlated with the ADP change rate (p < 0.05). CONCLUSION(S): Regular exercise results in an improvement of the serum irisin and ADP levels, the systemic metabolic markers, the islet beta-cell function, and insulin resistance in patients with T2DM.

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