BACKGROUND AND AIM: Coronary artery disease (CAD) is one of the leading causes of death and mortality in today's societies. Physical activity increases some of the influential factors for this disease. The purpose of this study was to investigate the effect of 8 weeks of aerobic and resistance training on endostatin in patients with coronary artery bypass graft (CABG). METHODS AND MATERIALS: The study participants were 24 male patients who were randomly divided into the experimental (n = 12) and control (n = 12) groups with mean +/- SD age of 55.37 +/- 6.90 years, weight 75.45 +/- 5.87 kg, height 173.27 +/- 3.36 cm and body mass index of 25.11 +/- 1.55 kg/m2. The experimental group performed 8 weeks of aerobic and resistance training (3 sessions per week and 1.5 hours per session) based on the measurements, while the control group did not exercise during this period. To measure endostatin concentrations, blood samples were taken 48 hours before and 48 hours after the last training session while all subjects were fasting. Data were analyzed using the Shapiro-Wilk test to normalize the data and student t-test in independent and correlated groups at the significant level of 0.05. ETHICAL CONSIDERATIONS: This article was ethically approved by Azad University of Neyshabur (ethics code IR.IAU.NEYSHABUR.REC.1398.018) and with the clinical trial code IRCT20191228045916N1 in the Iranian Registry of Clinical Trials. RESULTS: The present study showed that the aerobic and resistance training group significantly decreased endostatin concentrations (p = 0.001) (t = 1.672) compared with the control group. CONCLUSION: Based on the findings, aerobic and resistance training decreases endostatin concentrations, known as an anti-angiogenic factor.

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