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Resilient youth with neurofibromatosis: less perceived stress and greater life satisfaction after an 8-week virtual mind-body intervention
Lester E, Vranceanu A-M
Journal of Psychosocial Oncology 2021;39(5):680-685
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVES: The neurofibromatoses (NF) are rare, incurable genetic disorders. Adolescents with NF report greater stress and lower life satisfaction compared to same-age peers. We report on changes in life satisfaction and perceived stress following an 8-week single-blind, virtual randomized controlled trial of a mind-body intervention versus an educational control. METHODS: Adolescents (N = 51) completed measures at baseline, post-treatment (N = 45), and 6 months later (N = 39). RESULTS: Adolescents were geographically diverse, 41% female, and 76% white. Adolescents randomized to the intervention had greater improvements from baseline to post-test in stress compared to those in control; these were maintained through 6 months. Those randomized to intervention also reported greater improvement in life satisfaction from baseline to 6 months. CONCLUSIONS: The NF tailored mind-body program resulted in sustained reduction in stress and improved life satisfaction. A virtual model of mind-body care may help adolescents who face other chronic medical illness.

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