BACKGROUND: Chronic obstructive pulmonary disease (COPD), which is a disease characterized by dyspnea, cough, and respiratory symptoms, leading to impaired health-related quality of life (HRQL) and exercise capacity, is highly prevalent worldwide. Some studies demonstrated that acupuncture point stimulation treatments (APSTs) are effective and safe in treating patients with COPD. The aim of this systematic review and network meta-analysis is to analyze the effects on HRQL and FEV1% predicted of diverse APSTs in treating patients with COPD. MATERIALS AND METHODS: We searched seven electronic databases. Randomized controlled trials (RCTs) with stable COPD patients comparing APSTs and conventional treatment (Tx) were included. The primary outcome was HRQL measured by COPD Assessment Test or St George's Respiratory Questionnaire. The secondary outcome was FEV1% predicted. We performed random effect network meta-analysis using a consistency model. RESULTS: This network meta-analysis analyzed 21 RCTs with 1,577 stable COPD participants. In comparison with Tx, acupressure massage (AM) plus Tx (-5.11; 95% confidence interval (CI) -6.65 to -3.57) was the most effective intervention in improving HRQL, followed by moxibustion (Mx) plus Tx (-2.86; 95% CI -3.86 to -1.86). Moreover, in comparison with Tx, Mx+Tx (7.79; 95% CI 2.16 to 13.42) was the most effective intervention in improving FEV1% predicted, followed by acupuncture (A) plus Tx (5.79; 95% CI 2.90 to 8.68). CONCLUSIONS: Combined interventions (APSTs+Tx) are more effective than single intervention in improving both HRQL and FEV1% predicted. AM, Mx, and A can be considered effective non-pharmacological complementary interventions in treating patients with COPD under Tx.

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