BACKGROUND: This study assessed the feasibility of a phase II randomized controlled trial of high-intensity interval training (HIIT), resistance training (RT), and usual care (UC) in men with prostate cancer (PCa) on active surveillance (AS) and evaluated changes in clinically relevant outcomes. METHODS: Eighteen men undergoing AS for PCa were randomized to HIIT (n = 5), RT (n = 7), or UC (n = 6). Exercise participants attended two supervised sessions weekly and were instructed to complete one home-based session weekly for 8 weeks. UC participants were provided with physical activity guidelines. RESULTS: Feasibility was met for attendance, compliance, and retention, but not recruitment. HIIT increased leg press (mean +8.2 kg, 95%CI 1.1 to 15.3) from baseline to 8 weeks. RT increased seated row (mean +11.7 kg, 95%CI 6.1 to 17.3) and chest press (mean +10.4 kg, 95%CI 5.3 to 15.5), leg press (mean +13.1 kg, 95%CI 5.9 to 20.3), serum insulin-like binding protein-3 (IGFBP-3) (mean +400.0 ng/ml, 95%CI 94.5 to 705.5), and decreased interferon-gamma (mean -3.1 pg/ml, 95%CI -5.7 to -0.4). No changes were observed in the UC group. CONCLUSION: HIIT and RT may be effective strategies for improving muscle strength; however, only RT may increase serum IGFBP-3. Strategies that can enhance recruitment in men on AS are important prior to conducting a phase II trial. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov number NCT04266262.

Full text (sometimes free) may be available at these link(s):      help

• DOI
• PubMed
• PDF locator
• publisher