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The effects of high-intensity interval training versus moderate-intensity continuous training on inflammatory markers, body composition, and physical fitness in overweight/obese survivors of breast cancer: a randomized controlled clinical trial [with consumer summary]
Hooshmand Moghadam B, Golestani F, Bagheri R, Cheraghloo N, Eskandari M, Wong A, Nordvall M, Suzuki K, Pournemati P
Cancers 2021 Sep;13(17):4386
clinical trial
5/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Chronic inflammation associated with breast cancer (BC) poses a major challenge in care management and may be ameliorated by physical activity. This randomized controlled trial assessed the effects of a 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on inflammatory markers, body composition, and physical fitness in BC survivors (BCS). METHOD(S): Forty BCS (age 57 +/- 1 years; body mass (BM) 74.8 +/- 1.5 kg; VO2peak 20.8 +/- 2.1 mL/kg/min) were randomly assigned to three groups: HIIT (n = 15), MICT (n = 15), or control (CON; n = 15). The intervention groups (HIIT and MICT) performed their respective exercise protocols on a cycle ergometer 3 days/week for 12 weeks while the CON group maintained their current lifestyle. Baseline and post-intervention assessments included body composition (BM, fat mass (FM), lean mass (LM)), physical fitness (VO2peak, lower body strength (LBS), upper body strength (UBS)), and serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), leptin, and adiponectin. RESULT(S): Both intervention groups significantly (p < 0.05) decreased BM (HIIT -1.8 kg, MICT -0.91 kg), FM (HIIT -0.81 kg, MICT -0.18 kg), TNF-alpha (HIIT -1.84 pg/mL, MICT -0.99 pg/mL), IL-6 (HIIT -0.71 pg/mL, MICT -0.36 pg/mL), leptin (HIIT -0.35 pg/mL, MICT -0.16 pg/mL) and increased VO2peak (HIIT 0.95 mL/kg/min, MICT 0.67 mL/kg/min), LBS (HIIT 2.84 kg, MICT 1.53 kg), UBS (HIIT 0.53 kg, MICT 0.53 kg), IL-10 (HIIT 0.63 pg/mL, MICT 0.38 pg/mL), and adiponectin (HIIT 0.23 ng/mL, MICT 0.1 ng/mL) compared to baseline. The changes in BM, FM, TNF-alpha, leptin, and LBS were significantly greater in HIIT compared to all other groups. CONCLUSION(S): Our findings indicate that compared to the often-recommended MICT, HIIT may be a more beneficial exercise therapy for the improvement of inflammation, body composition and LBS in BCS; and consequently, merits long-term study.

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