The purpose of this study was to determine whether interventions could improve peroneal reaction time in both healthy and those with injured ankle participants based on a systematic review and meta-analysis. An electronic search of the following database was carried out: Medline, ScienceDirect and SPORTDiscus (1965 to 2020). Studies utilising sudden ankle inversion to measure peroneal reaction times were selected. 28 studies were included for the systematic review, and 18 studies for the meta-analysis. The peroneal reaction time for pre-and post-intervention were compared into two groups, group 1 was therapeutic exercise intervention, and group 2 was prophylactic devices. The results showed a statistically significant difference in reduced peroneal reaction time in favour of participants in the exercise group (SMD 0.74, 95%CI 1.09 to 0.39, p < 0.001, I2 = 80%), while the prophylactic devices group showed no significant difference between control and intervention group. The effect size measured was 0.81 and 0.31 in group 1 and group 2, respectively. Faster peroneal muscle onset reaction time post-intervention, which was found following therapeutic exercise, should be considered for rehabilitation and preventing of ankle sprain injury.

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