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High-intensity interval training versus progressive high-intensity circuit resistance training on endothelial function and cardiorespiratory fitness in heart failure: a preliminary randomized controlled trial
Turri-Silva N, Vale-Lira A, Verboven K, Quaglioti Durigan JL, Hansen D, Cipriano G Jr
PLoS ONE 2021 Oct;16(10):e0257607
clinical trial
7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

INTRODUCTION: Exercise training is strongly recommended as a therapeutic approach to treat individuals with heart failure. High-intensity exercise training modalities still controversial in this population. The study aims to preliminary assess the consequences of high-intensity exercise training modalities, aerobic interval training (HIIT) and progressive high circuit-resistance training (CRT), on primarily endothelial function and cardiorespiratory fitness, and secondly on muscle strength and physical performance in heart failure patients. METHODS: This preliminary multicentric randomized controlled trial comprised 23 heart failure patients, aged 56 +/- 10 years old, mainly New York Heart Association classification I and II (%), hemodynamically stable, who compromise at least 36 exercise sessions of a randomly assigned intervention (HIIT, CRT or control group). Endothelial function, cardiopulmonary exercise testing, muscle strength and physical performance were completed at baseline and post-intervention. RESULTS: Although no effects on endothelial function; both HIIT and CRT modalities were able to produce a positive effect on VO2peak (HIIT +2.1 +/- 6.5, CRT +3.0 +/- 4.2 and control group -0.1 +/- 5.3 mL/kg/min, time x group p-value < 0.05) and METs (HIIT +0.6 +/- 1.8, CRT +0.9 +/- 1.2 and control group 0 +/- 1.6, time x group p-value < 0.05). Only HIIT increased isokinetic torque peak (HIIT +8.8 +/- 55.8, CRT 0.0 +/- 60.7 and control group 1.6 +/- 57.6 Nm) matched p-value < 0.05. Regarding the physical performance, the CRT modality reduced chair stand test completion time (HIIT -0.7 +/- 3.1, CRT -3.3 +/- 3.2 and control group -0.3 +/- 2.5 s, matched p-value < 0.05 and HIIT improved global physical performance (time x group p < 0.05). CONCLUSION: This preliminary study trends to indicate for the first time that high-intensity interval training promotes a jointly superior effect compared to progressive high intensity circuit-resistance training by improving cardiorespiratory fitness, muscular strength, and physical performance. Further research with larger cohort is necessary. CLINICAL TRIAL REGISTRATION NUMBER: ReBEC RBR-668c8v.

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