OBJECTIVE: To evaluate the bone response to an 8 month aerobic gymnastics training program in young opioid-addicted women. DESIGN: Randomized controlled trial (parallel design). SETTING: Women's Specific Drug Rehabilitation Center in China. PATIENTS: One hundred and two young women with low bone quality and previous opioid addiction were divided into two groups: (a) the low bone quality intervention experimental group (n = 55; age 30.3 +/- 6.1) and (b) the low bone quality observed control group (observation group; n = 47; age 29.0 +/- 5.3). INTERVENTIONS: The intervention group took aerobic gymnastics regularly for 80 min/d and 5 d/wk for 8 months and completed follow-up testing. MAIN OUTCOME MEASURES: Substance use history and other life habits affecting bone quality were assessed by questionnaire-based interviews. Bone quality (stiffness-index, t-score, z-score) was examined with quantitative ultrasound. Anthropometric characteristics (body weight, fat-free mass, fat mass) were obtained by bioelectrical impedance analysis. RESULTS: After the 8 month intervention, the stiffness index of bone quality increased significantly (before 82 +/- 6, after 108 +/- 14, p < 0.05) in the experimental group. However, the bone quality did not change significantly in the controls (before 79 +/- 10, after 77 +/- 13, p > 0.05). The bone change in the difference group was significant (experimental group 31.7% versus observation group -0.03%). Fat mass decreased in the experimental group (experimental group before 19.6 +/- 3.7 kg, after 18.8 +/- 4.0 kg, p < 0.05). Meanwhile, the change in fat-free mass was the determination of the change in bone quality in the experimental group. CONCLUSIONS: Our results suggested that aerobic gymnastics intervention can be an effective strategy for the prevention and treatment of drug-induced osteoporosis in detoxification addicts.

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