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| A comparison of methods of discontinuing nasal CPAP in premature infants < 30 weeks gestation: a feasibility study |
| Duyka B, Beaullieu C, Khan AM |
| Journal of Perinatology 2021 Nov;41(11):2658-2663 |
| clinical trial |
| 7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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OBJECTIVE: The objective of this study was to determine whether abrupt discontinuation versus gradual wean of nasal CPAP (NCPAP) in infants < 30 weeks gestation results in a decreased duration of NCPAP therapy. STUDY DESIGN: We performed a single-center, randomized control trial of premature infants born < 30 weeks gestation (n = 66), comparing discontinuation of NCPAP from 6 cmH2O (CWP) (fast wean arm) to discontinuation at 4 CWP, weaning by 1 CWP per day (slow wean arm). The primary outcome was the total number of days on NCPAP or mechanical ventilation. Secondary outcomes included wean failure, growth, length of stay, and related comorbidities. RESULTS: Duration of NCPAP or mechanical ventilation was longer in the slow wean arm compared to the fast wean arm (17 versus 12 days, p = 0.03). There were no differences observed in secondary outcomes. CONCLUSION: In weaning NCPAP, abrupt discontinuation may be associated with a shorter duration of positive pressure respiratory support compared to a gradual weaning strategy.
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