OBJECTIVE: To review the cost-effectiveness of multifactorial interventions to prevent falls in elderly people. METHODS: In this systematic review, the databases including PubMed via Medline, Web of Science, Embase, Scopus, the Cochrane Library and Google Scholar (from 1st January 2000 to 30th February) were used. All pre-reviewed articles related to cost-effectiveness analysis of multifactorial interventions to prevent falls in elderly were included in this paper and congresses abstracts were excluded. Descriptive statistics were used for quantitative data and content-analysis method to analyze qualitative data. RESULTS: Out of the 456 articles, 19 were finally included in the study. Eighteen articles were conducted in High-Income Countries (HICs) and 16 were at the community level. Medical visits consultation and education were the most common interventions. Most studies were cost-effectiveness and using the Randomized Control Trial (RCT) methods. A fall of prevention costs ranged from $272 to $987. Incremental Cost-Effectiveness Ratio (ICER) interventions also ranged from US $120,667 to US $4280.90. CONCLUSION: The results show that despite the high effectiveness of multifactorial interventions to prevent elderly falls, the cost of the interventions are high and they are not very cost-effective. It would be better to design and implement multifactorial interventions with low cost and high effectiveness that are appropriate for each country.

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