In this prospective study, we used the random number table method to equally divide 141 patients with chronic nonspecific low back pain (CNLBP) who met the inclusion criteria into 3 groups. One group who received massage manipulation therapy was recorded as the manipulation group (n = 47), one other group who received core strength training therapy was recorded as the training group (n = 47), and the other group who received massage manipulation combined with core strength training was recorded as the combination group (n = 47). All the patients were treated for 1 week as the course of treatment, with the treatment conducted for 5 days/week for 4 weeks and 12 weeks of follow-up. The efficacies of the 3 groups were evaluated after treatment, and the visual analogue scale (VAS) scores, Oswestry Disability Index (ODI) scores, and waist dynamic and static muscle endurance before and after treatment of the 3 groups were compared, and the long-term efficacies of the 3 groups were evaluated combined with the VAS scores at 6 weeks and 12 weeks after treatment. Our result was that, after treatment, the total effective rate of the combination group (95.74%) is significantly better than that of the manipulation group (80.85%) and the training group (78.72%) (p < 0.05). After treatment, the VAS and ODI scores of the 3 groups significantly decreased, and the waist dynamic endurance and static muscle endurance significantly increased, and the condition of the combination group was significantly improved compared with that of the manipulation group and the training group (p < 0.05). At 6 weeks and 12 weeks after treatment, the VAS scores of the manipulation group and training group were increased compared with those at the end of treatment (p < 0.05), there was no significant change in the combination group (p < 0.05), and the VAS scores of the combination group at 6 weeks and 12 weeks after treatment were lower than those of the manipulation group and training group at the same time point (p < 0.05). This suggests that the synergistic effect of massage manipulation combined with core strength training in the treatment of CNLBP can effectively alleviate patients' pain and waist dysfunction, enhance dynamic and static muscle endurance, and have significant short-term and long-term effects, which are worthy of promotion.

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