OBJECTIVE: To investigate whether motion-control shoes reduce the risk of pronation related injuries in recreational runners. DESIGN. Secondary analysis of a randomized controlled trial of the effect of shoes on running, injuries. METHODS: Three hundred seventy-two recreational runners were randomized to receive either standard neutral or motion-control shoes and were followed up for 6 months regarding running activity and injury. Running injuries that occurred during this period were registered and classified as pronation related injuries (Achilles tendinopathy, plantar, fasciopathy, exercise-related lower-leg pain, and anterior knee pain) or other running related injuries. With the use of competing risk analysis, the relationship between pronation related and other running-related injuries and shoe type was evaluated by estimating the cause-specific hazard controlling for other possible confounders like age, sex, body mass index, previous injury, and sport participation pattern. RESULTS: Twenty-five runners sustained pronation-related running injuries and 68 runners, sustained other running-related injuries. Runners wearing the motion-control shoes had a lower risk of pronation-related running injuries compared with runners who wore standard neutral shoes (hazard ratio 0.41; 95% confidence interval 0.17 to 0.98). There was no effect of shoe type (hazard ratio 0.68.95% confidence interval 0.41 to 1.10) on the risk of other running-related injuries. CONCLUSION: Motion-control shoes may, reduce the risk of pronation-related running injuries, but did not influence the risk of other running related injuries.

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