This study compared the short-term continuously monitored glucose responses between higher and lower amounts of prolonged sitting in overweight and obese adults under free-living conditions. In a randomised crossover design, 12 participants (age 48 +/- 10 years, body mass index 33.3 +/- 5.5 kg/m2) completed two four-day experimental regimens while wearing a continuous glucose monitor, as follows: (1) uninterrupted sitting (participants were instructed to sit for >= 10 h/day and accrue >= 7, 1 h sitting bouts each day), and (2) interrupted sitting (participants were instructed to interrupt sitting every 30 min during ten of their waking hours with 6 to 10 min of activity accrued in each hour). Linear mixed models compared outcomes between regimens. None of the continuously monitored glucose variables differed between regimens, eg, 24 h net incremental area under the glucose curve was 5.9 (95% CI -1.4 to 13.1) and 5.6 (95% CI -1.7 to 12.8) mmol/L/24 h, respectively (p = 0.47). Daily sitting (-58 min/day, p = 0.001) and sitting bouts lasting >= 30 min (-99 min/day, p < 0.001) were significantly lower and stepping time significantly higher (+40 min/day, p < 0.001) in the interrupted sitting than the uninterrupted sitting regimen. In conclusion, lower amounts of daily and prolonged sitting did not improve free-living continuously measured glucose among overweight and obese adults.

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