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Clinical effects of relaxation training combined with paracetamol and tramadol hydrochloride tablets on patients with chronic pain
Yu Y, Chen Z, Wang Y, Mu R
International Journal of Clinical and Experimental Medicine 2020;13(9):6902-6908
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: This study was designed to investigate the effect of relaxation training combined with paracetamol and tramadol hydrochloride tablets in the treatment of chronic pain from the aspects of pain relief, anxiety and depression, quality of life and adverse reactions. METHODS: A total of 94 patients with chronic pain admitted to our hospital from January 2018 to December 2019 were selected and divided into the study group (SG, n = 47) and the control group (CG, n = 47) by a random number table. Paracetamol and tramadol hydrochloride tablets were given to all patients included, and relaxation training was additionally provided to the patients in the SG. The two groups were compared for the pain relief, scores of anxiety and depression, quality of life and adverse reactions. RESULTS: (1) After treatment, the pain relief and incidence of adverse reactions were 95.74% and 19.15% in the SG; 74.47% and 44.68% in the OG (p < 0.05). (2) The scores of anxiety and depression at 2 weeks and 4 weeks after treatment were significantly lower in the SG (p < 0.05), but at 1 week after treatment, the SG demonstrated a significantly higher score of depression (p < 0.05). Both groups achieved significant decreases in the scores of anxiety and depression at 1 week, 2 weeks and 4 weeks after treatment (p < 0.05); (3) There was no significant difference in quality of life in both groups before treatment (p > 0.05). After treatment, the scores for physical role (PR), physical function (PF), cognitive function (CF), emotional function (EF), role function (RF) and total score of quality of life were significantly increased in both groups (p < 0.05), and the SG achieved higher scores than the CG (p < 0.05). CONCLUSION: The combination of relaxation training and paracetamol and tramadol hydrochloride can effectively relieve pain, anxiety and depression, reduce adverse reactions, and have a positive effect on improving the quality of life of patients.

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