OBJECTIVE: To examine the amount of objectively measured MVPA and LPA that is associated with long-term weight loss and the maintenance of clinically significant weight loss. METHODS: Adults (N = 260; BMI: 25 to < 40 kg/m2; age: 18 to 55 years) participated in an 18-month behavioral weight loss intervention and were prescribed a low-calorie diet and increased physical activity. Change in weight and objectively measured physical activity were assessed. MVPA > 10 (MET-min/week) was computed from bouts > 10 min and > 3.0 METs and MVPA < 10 was computed from bouts < 10 min in duration and > 3.0 METs. LPA was computed from bouts between 1.5 to < 3.0 METs. RESULTS: When grouped on percent weight loss at 18 months, there was a significant group x time interaction effect (p < 0.0001) for both MVPA > 10 and LPA, with both measures being significantly greater at 18 months in those with > 10% weight loss. Similar results were observed for MVPA > 10 and LPA with participants grouped on achieving > 10% weight loss at 6 months and sustaining this at 18 months. CONCLUSIONS: MVPA > 10 of 200 to 300 min per week, coupled with increased amounts of LPA, are associated with improved long-term weight loss. Interventions should promote engagement in these amounts and types of physical activity.

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