BACKGROUND AND OBJECTIVES: Muscle weakness and fatigue decrease the functional capacity and quality of life of multiple sclerosis patients. Although routine exercise is acceptable in these patients, its impact has not been proven. The aim of this study was to assess the effect of exercise on muscular performance and function, degree of disability, fatigue, and quality of life of patients with MS. METHODS: Twenty-four women aged 20 to 50 years old with multiple sclerosis and an expanded disability status scale (EDSS) of 2 to 5 were randomly divided into two groups of control (12 patients) and case (12 patients). The training program included three sessions per week, lasting for 12 weeks (two sessions of aerobic training and one session of resistance training). RESULTS: The results showed that 12 weeks of combined training caused a significant improvement in lower body strength (p = 0.019), upper body strength (p = 0.001), dynamic balance (p = 0.025), gait speed (p = 0.008), endurance (p = 0.0001), quality of life (p = 0.007) and a significant decrease in the degree of disability (p = 0.007) and fatigue (p = 0.001). CONCLUSIONS: In general, a combined training program, including aerobic and resistance training, in three non-consecutive days per week is helpful for women with MS and improves their sensorimotor function. The relevant specialists can use these exercises along drug therapy to reduce the clinical complications of MS.

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