OBJECTIVE: To synthesize the evidence examining caregiver-mediated mobility interventions in a hospital setting and whether they improve patient, caregiver, or health system outcomes. DATA SOURCES: We searched Medline, Embase, PsycINFO, CINAHL, and Scopus databases from inception to September 7, 2018. STUDY SELECTION: Two reviewers independently selected original research in inpatient settings that reported on an intervention delivered by a caregiver (eg, family, friend, paid worker) and directed to the patient's mobility. Mobility interventions were categorized based on the level of caregiver engagement using a 3-category framework: inform (provision of education on patient's condition and management), activate (prompting caregivers to take action in patient care), and collaborate (encouraging interaction with providers or other caregivers). DATA EXTRACTION: One reviewer extracted data, and another checked the data. Quality was assessed using the Cochrane Collaboration's risk of bias tool and Grading of Recommendations, Assessment, Development and Evaluation approach. DATA SYNTHESIS: Forty studies met the inclusion criteria; most were randomized controlled trials (n = 16/40, 40.0%) and investigated older adults (n = 18/40, 45.0%) with stroke (n = 20/40, 50.0%). Inform (n = 2) and activate (n = 4) interventions and combined inform-activate (n = 5/6, 83.3%) and inform-activate-collaborate (n = 6/10, 60.0%) interventions were reported to improve patient mobility. Inform-activate and inform-collaborate interventions were reported to improve caregiver outcomes (eg, burden) (n = 13/19, 68.4%). Studies that engaged caregivers in all 3 strategies (inform-activate-collaborate) were reported to improve health system outcomes (eg, hospital readmission) (n = 4/6, 66.7%). Most studies were of unclear (n = 22/40, 55.0%) or low risk of bias (n = 11/40, 27.5%) for most domains. CONCLUSIONS: Engaging caregivers in mobility of hospitalized patients may improve patient mobility as well as caregiver and health system outcomes.

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