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| Effect of aerobic exercise training frequency on arterial stiffness in middle-aged and elderly females | 
| Kobayashi R, Asaki K, Hashiguchi T, Negoro H | 
| Journal of Physical Therapy Science 2022 May;34(5):347-352 | 
| clinical trial | 
| 5/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* | 
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                     PURPOSE: This study aimed to determine the effects of aerobic exercise training frequency on arterial stiffness in postmenopausal females. PARTICIPANTS AND METHODS: This study included 45 postmenopausal females randomly assigned to one of the following three groups: (1) low-frequency training group (aerobic exercise training twice per week); (2) high-frequency training group (aerobic exercise training four times per week); and (3) control group (no training). Each group was subjected to an 8-week intervention period. Both traditional and newer indexes were measured immediately before and after the 8-week intervention period. RESULTS: In the low-frequency training group, carotid-femoral pulse wave velocity and arterial velocity pulse index decreased post 8 weeks compared with those at baseline. In the high-frequency training group, carotid-femoral, brachial-ankle, and heart-brachial pulse wave velocities and arterial velocity pulse and arterial pressure-volume indexes decreased post 8 weeks compared to those at baseline. In the control group, no change in any indices post 8 weeks compared to those at baseline was observed. CONCLUSION: Carotid-femoral pulse wave velocity was lower after aerobic training than before training in both the exercise groups. Thus, aerobic exercise training might have a beneficial effect on aortic stiffness, regardless of the training frequency in this population.  
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