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| Intensity dependent effects of interval resistance training on myokines and cardiovascular risk factors in males with obesity |
| Ataeinosrat A, Saeidi A, Abednatanzi H, Rahmani H, Daloii AA, Pashaei Z, Hojati V, Basati G, Mossayebi A, Laher I, Alesi MG, Hackney AC, VanDusseldorp TA, Zouhal H |
| Frontiers in Endocrinology 2022 Jun 10;13(895512):Epub |
| clinical trial |
| 4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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OBJECTIVE: To determine the effects of different intensities of interval resistance training (IRT) protocols on the levels of select myokines (decorin, follistatin, myostatin, activin A, transforming growth factor beta-1 (TGF-beta1)), and cardiometabolic and anthropometric measures in males with obesity. METHODS: Forty-four obese males (age 27.5 +/- 9.4 yr.; height 165.4 +/- 2.8 cm; weight 97.9 +/- 2.6 kg and BMI 35.7 +/- 4.3 kg/m2) were randomly assigned to one of four groups (n = 11 per group): low-intensity interval resistance training (LIIRT), moderate-intensity interval resistance training (MIIRT), high-intensity interval resistance training (HIIRT) or control (C). The LIIRT group performed 10 exercises in 3 sets of 40% (20 repetitions), the MIIRT group performed 10 exercises in three sets of 60% (13 repetitions), and the HIIRT group performed 10 exercises in three sets of 80% (10 repetitions) of one maximum repetition (1RM), which were followed with active rest of 20% of 1RM and 15 repetitions. The resistance training groups exercised ~70 min per session, 3 days per week, for 12 weeks. Measurements were taken at baseline and after 12 weeks of exercise training. RESULTS: Baseline levels of myokines, cardiovascular risk factors, anthropometry, body composition, and cardio-respiratory fitness were not different between the four groups (p > 0.05). The group x time interactions for decorin, activin A, follistatin, myostatin, and TGF-beta1, total cholesterol (TC), triglyceride (TG), high-density cholesterol (HDL), low-density cholesterol (LDL), anthropometry, body composition, and cardio-respiratory fitness were statistically significant (p < 0.05). There were increases in post-test values for decorin, follistatin, HDL (p < 0.05) and decreases in TC, TG, TGF-beta1, LDL, and myostatin levels in the LIIRT, MIIRT, and HIIRT groups compared to pretest values (p < 0.05). Changes in fat mass, VO2peak, HDL, TG, glucose, activin A, decorin were not significant in LIIRT compared to the control group, while changes in activin A, follistatin, and TFG-beta1 levels were greater in HIIRT and MIIRT groups compared to the LIIRT group (p < 0.05). CONCLUSION: The LIIRT, MIIRT, and HIIRT protocols all produced beneficial changes in decorin, activin A, follistatin, myostatin, and TGF-beta1 levels, and cardiometabolic risk factors, with greater effects from the MIIRT and HIIRT protocols compared to LIIRT.
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