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Intensity dependent effects of interval resistance training on myokines and cardiovascular risk factors in males with obesity
Ataeinosrat A, Saeidi A, Abednatanzi H, Rahmani H, Daloii AA, Pashaei Z, Hojati V, Basati G, Mossayebi A, Laher I, Alesi MG, Hackney AC, VanDusseldorp TA, Zouhal H
Frontiers in Endocrinology 2022 Jun 10;13(895512):Epub
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To determine the effects of different intensities of interval resistance training (IRT) protocols on the levels of select myokines (decorin, follistatin, myostatin, activin A, transforming growth factor beta-1 (TGF-beta1)), and cardiometabolic and anthropometric measures in males with obesity. METHODS: Forty-four obese males (age 27.5 +/- 9.4 yr.; height 165.4 +/- 2.8 cm; weight 97.9 +/- 2.6 kg and BMI 35.7 +/- 4.3 kg/m2) were randomly assigned to one of four groups (n = 11 per group): low-intensity interval resistance training (LIIRT), moderate-intensity interval resistance training (MIIRT), high-intensity interval resistance training (HIIRT) or control (C). The LIIRT group performed 10 exercises in 3 sets of 40% (20 repetitions), the MIIRT group performed 10 exercises in three sets of 60% (13 repetitions), and the HIIRT group performed 10 exercises in three sets of 80% (10 repetitions) of one maximum repetition (1RM), which were followed with active rest of 20% of 1RM and 15 repetitions. The resistance training groups exercised ~70 min per session, 3 days per week, for 12 weeks. Measurements were taken at baseline and after 12 weeks of exercise training. RESULTS: Baseline levels of myokines, cardiovascular risk factors, anthropometry, body composition, and cardio-respiratory fitness were not different between the four groups (p > 0.05). The group x time interactions for decorin, activin A, follistatin, myostatin, and TGF-beta1, total cholesterol (TC), triglyceride (TG), high-density cholesterol (HDL), low-density cholesterol (LDL), anthropometry, body composition, and cardio-respiratory fitness were statistically significant (p < 0.05). There were increases in post-test values for decorin, follistatin, HDL (p < 0.05) and decreases in TC, TG, TGF-beta1, LDL, and myostatin levels in the LIIRT, MIIRT, and HIIRT groups compared to pretest values (p < 0.05). Changes in fat mass, VO2peak, HDL, TG, glucose, activin A, decorin were not significant in LIIRT compared to the control group, while changes in activin A, follistatin, and TFG-beta1 levels were greater in HIIRT and MIIRT groups compared to the LIIRT group (p < 0.05). CONCLUSION: The LIIRT, MIIRT, and HIIRT protocols all produced beneficial changes in decorin, activin A, follistatin, myostatin, and TGF-beta1 levels, and cardiometabolic risk factors, with greater effects from the MIIRT and HIIRT protocols compared to LIIRT.

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