OBJECTIVES: This study aimed to demonstrate potential translation of pre-clinical studies to a home-based exercise intervention in mediating inflammatory cytokine markers and tumor progression in men under active surveillance for prostate cancer. METHODS: A 2-arm randomized control parallel group design was used. The exercise intervention consisted of 24 weeks of an aerobic and resistance home-based exercise program and results were compared to a waitlist control group. Data were collected at baseline and end of study for eotaxin, interferon-gamma (INF-gamma), interleukin-12 (IL-12), interleukin-1alpha (IL-1alpha), interleukin-5 (IL-5), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and vascular endothelial growth factor (VEGF), distanced walked during a 6-Minute Walk Test (6MWT), Body Mass Index, and Health-Related Quality Of Life. RESULTS: Non-significant decreases were observed in all biomarkers, especially VEGF (pre: 125.16 +/- 198.66, post: 80.29 +/- 124.30, p = 0.06) and INF-gamma (pre: 152.88 +/- 312.71, post: 118.93 +/- 158.79, p = 0.08), in the intervention group; only IL- alpha (pre: 332.15 +/- 656.77, post: 255.12 +/- 502.09, p = 0.20) decreased in the control group while all other biomarkers increased from baseline to end of study. A non-significant increase in 6MWT distance was observed in the intervention group, while a decrease was seen in the control group. Significant decreases in physical function, emotional wellbeing, and total composite scale on the FACIT-F were observed in the intervention group, possibly due to the isolation restrictions of COVID-19. Physical function on the SF-36 significantly increased in the control group. CONCLUSIONS: Future studies with powered samples are needed to confirm the trends observed for inflammatory biomarkers and functional fitness.

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