OBJECTIVE: To compare the effects of core stabilization (CS) and dynamic neuromuscular stabilization (DNS) on balance, trunk function, mobility, falling, and spasticity, in People with Multiple Sclerosis (PWMS). DESIGN: Two-group randomized controlled trial. SETTING: general community and referral center. PARTICIPANTS: A total of 64 PWMS, between 30 and 50 years old, and an expanded disability status scale (EDSS) between 2 and 5, participated in this study. INTERVENTIONS: Participants were randomly assigned to CS (n = 32) and DNS (n = 32) groups. Both groups received a total of 15 sessions of CS or DNS exercises, 60 minutes per session, three times a week during the 5 weeks. OUTCOME MEASURES: Balance function was measured as the primary outcome measure. Trunk function, postural stability, falling rate, fear of falling, falling index, mobility, and spasticity, were measured as secondary outcomes. RESULTS: DNS group had significant improvement in Berg Balance Scale (BBS), Trunk Impairment Scale (TIS), postural stability, Activities-specific Balance Confidence (ABC), reduced falling rate, the Timed Up and Go (TUG), Multiple Sclerosis Walking Scale-12 (MSWS), and Multiple Sclerosis Spasticity Scale-88 (MSSS) in PWMS compared with the CS group, (p < 0.0001) after 5 weeks of intervention and 17 weeks of follow-up. Except for the Modified Ashworth Scale (MAS), significant improvements were seen in all outcome measures in both groups after 5 weeks of intervention. CONCLUSION: This is the first clinical evidence to support the importance of DNS exercise in improving balance, trunk function, and fall prevention in PWMS. This study provides clinical evidence that DNS may be more effective for PWMS than CS.

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