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Effect of high-intensity aerobic exercise versus moderate-intensity aerobic exercise on serum uric acid in hypertension
Mahmoud TH, Ahmed MS, Saleh HM, Abdelhakiem NM, Elhameed REA, Allah MAG
NeuroQuantology 2022 Apr;20(4):552-563
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND AND PURPOSE: METHODS: Thirty hypertensive men (Mild Essential Hypertension) with ages ranging from 45 to 55 years old and BMIs ranging from 25 to 35 kg/m2 took part in the study (overweight and class1 obesity). The participants were classified randomly into two main domains; A and B. As for the first Group, (A) did high-intensity (interval) aerobic activity, while group (B) did moderate-intensity (continuous) aerobic exercise. Both categories exercised for 30 to 40 minutes on an electrical treadmill three times a week for eight weeks. Blood uric acid, serum creatinine, and serum urea were tested for each patient before and after the trial. The arterial blood pressure measurements were also taken before and after the study to draw comparisons and to set evaluations. RESULTS: Both high-intensity interval and continuous moderate exercise had a significant lowering effect on serum uric acid and creatinine (p.05), with continuous moderate exercise having a better effect with a 16 percent improvement in serum uric acid and a 27.5 percent improvement in creatinine, while high-intensity interval exercise had an 8 percent improvement in serum uric acid and a 17 percent improvement in creatinine. On the other hand, arterial blood pressure and blood urea levels improved at the same rate. CONCLUSIONS: Moderate continuous exercise reduces serum uric acid and creatinine better than high-intensity interval exercise. Both have the same effect on blood pressure and urea, but moderate continuous exercise has a crystal-clear effect that cannot be denied.

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