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Resistance training improves sleep and anti-inflammatory parameters in sarcopenic older adults: a randomized controlled trial
de Sa Souza H, de Melo CM, Piovezan RD, Miranda R, Carneiro-Junior MA, Silva BM, Thomatieli-Santos RV, Tufik S, Poyares D, D'Almeida V
International Journal of Environmental Research & Public Health 2022 Dec;19(23):16322
clinical trial
7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Sleep and exercise have an important role in the development of several inflammation-related diseases, including sarcopenia. OBJECTIVE: To investigate the effects of 12 weeks of resistance exercise training on sleep and inflammatory status in sarcopenic patients. METHODS: A randomized controlled trial comparing resistance exercise training (RET) with a control (CTL) was conducted. Outcomes were obtained by physical tests, polysomnography, questionnaires, isokinetic/isometric dynamometry tests, and biochemical analysis. RESULTS: Time to sleep onset (sleep latency) was reduced in the RET group compared to the CTL group (16.09 +/- 15.21 versus 29.98 +/- 16.09 min; p = 0.04) after the intervention. The percentage of slow-wave sleep (N3 sleep) was increased in the RET group (0.70%, CI 7.27 to 16.16 versus -4.90%, CI 7.06 to 16.70; p = 0.04) in an intention to treat analysis. Apnea/hour was reduced in the RET group (16.82 +/- 14.11 versus 7.37 +/- 7.55; p = 0.001) and subjective sleep quality was improved compared to the CTL (-1.50; CI 2.76 to 6.14 versus 0.00; CI 1.67 to 3.84 p = 0.02) in an intention-to-treat analysis. Levels of interleukin-10 (IL-10) (2.13 +/- 0.80 versus 2.51 +/- 0.99; p < 0.03) and interleukin-1 receptor antagonist (IL-1ra) (0.99 +/- 0.10 versus 0.99 +/- 0.10 ng/mL; p < 0.04; delta variation) were increased in the RET group. CONCLUSIONS: RET improves sleep parameters linked to muscle performance, possibly due to an increase in anti-inflammatory markers in older sarcopenic patients.

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