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| Chronic obstructive pulmonary disease patients with high peripheral blood eosinophil counts have better predicted improvement in 6MWD after rehabilitation: a preliminary study |
| Shui L-L, Cai J-J, Zhong X-Q, Li Y-L, He M-R, Chen Y-J |
| Journal of Cardiopulmonary Rehabilitation and Prevention 2023 Mar;43(2):122-128 |
| clinical trial |
| 4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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PURPOSE: The objective of this investigation was to determine whether chronic obstructive pulmonary disease (COPD) patients with high blood eosinophil (EOS) counts had better improvement in 6-min walk test (6MWT) after pulmonary rehabilitation (PR). METHODS: Fifty COPD patients were randomly assigned to either the rehabilitation group (RG) or the control group (CG). Patients in the RG (8 week PR plus routine medication) and the CG (routine medication) were followed for 32 week. According to the blood EOS level, the RG was divided into an EOS >= 200 cells/muL group and EOS < 200 cells/muL group. The 6MWT distance, Borg Scale, and COPD Assessment Test (CAT) were evaluated before intervention and 8 week and 32 week later. RESULTS: After the 8-week intervention, 37 patients (19 RG/18 CG) completed the study. At 8-week and 32-week follow-up from baseline, a statistically significant difference was found between these two groups in the 6MWT, Borg Scale, and CAT. Compared with baseline, the 6MWT in the RG increased 49.1 +/- 40.2 m (95% CI 29.7 to 68.5, p < 0.001) at 8 week and 60.8 +/- 42.1 m (95% CI 40.5 to 81.6, p < 0.001) at 32 week. In addition, the improvement of 6MWT in the EOS >= 200 cells/muL RG group was higher than that in the EOS < 200 cells/muL group (40.1 +/- 17.6 m, 95% CI 36.8 to 43.4; p = 0.036) at 32-week follow-up from baseline. CONCLUSION: An 8-week PR can improve the exercise capacity of COPD patients, and the benefits persistent for 24 week. The improvement in the 6MWT was more significant in COPD patients with a high blood EOS count.
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