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| The effect of threshold inspiratory muscle training on the duration of weaning in intensive care unit-admitted patients: a randomized clinical trial |
| Khodabandeloo F, Froutan R, Yazdi AP, Shakeri MT, Mazlom SR, Moghaddam AB |
| Journal of Research in Medical Sciences 2023;28(44):Epub |
| clinical trial |
| 5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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BACKGROUND: The purpose of this study was to evaluate the effect of threshold inspiratory muscle training (IMT) on the duration of weaning in intensive care unit (ICU)-admitted patients. MATERIALS AND METHODS: This randomized clinical trial enrolled 79 ICU-admitted, mechanically ventilated patients in 2020 to 2021 in Imam Reza Hospital, Mashhad. Patients were randomly divided into intervention (n = 40) and control (n = 39) groups. The intervention group received threshold IMT and conventional chest physiotherapy, while the control group only received conventional chest physiotherapy once a day. Before and after the end of the intervention, the strength of inspiratory muscles and the duration of weaning were measured in both the groups. RESULTS: The duration of weaning was shorter in the intervention group (8.4 +/- 1.1 days) versus the control group (11.2 +/- 0.6 days) (p < 0.001). The rapid shallow breathing index decreased by 46.5% in the intervention group and by 27.3% in the control group after the intervention (both p < 0.001), and the between-group comparison showed a significantly higher reduction in the intervention group than control group (p < 0.001). The patients' compliance after the intervention compared to the 1st day increased to 16.2 +/- 6.6 in the intervention group and 9.6 +/- 6.8 in the control group (both p < 0.001), and the between-group comparison showed a significantly higher increase in the intervention group than control group. The maximum inspiratory pressure increased by 13.7 +/- 6.1 in the intervention group and by 9.1 +/- 6.0 in the control group (p < 0.001). Furthermore, the weaning success was 54% more probable in the intervention group than control group (p < 0.05). CONCLUSION: The results of this study showed the positive effect of IMT with threshold IMT trainer on increased strength of respiratory muscles and reduced weaning duration.
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