OBJECTIVE: To systematically evaluate the effect of acupoint sticking application for rheumatoid arthritis, and to provide clinical evidence-based. METHODS: Literatures were available by searching the database including CNKI, Wanfang Data, VIP, CBM, PubMed, Embase and Cochrane library, and then two independent researchers respectively screened and determined the final inclusion literatures in the study. Using Assessing risk of bias in Cochrane Handbook evaluated the quality of literatures, and finally made a Meta analysis using Rev Man 5.3 software. RESULTS: Acupoint sticking application combined with conventional western medicine was more efficient than conventional western medicine (OR 3.32, 95% CI (1.87 to 5.90), Z = 4.10, p < 0.01), Acupoint sticking application was superior to other groups in VAS respect (SMD -0.42, 95% CI (-0.66 to -0.18), Z = 3.46, p < 0.01), Compared with conventional western medicine, acupoint sticking application with conventional western medicine can relieve the clinical symptoms of rheumatoid arthritis such as morning stiffness (MD -11.95, 95% CI (-17.73 to -6.17), Z = 4.05, p < 0.01), arthroncus (MD -1.75, 95% CI (-2.07 to -1.43), Z = 10.72, p < 0.01), joint tenderness (MD -1.88, 95% CI (-2.33 to -1.43), Z = 8.14, p < 0.01). CONCLUSION: Acupoint sticking application can improve the clinical effect of rheumatoid arthritis, and at the same time, multi-center, large-sample, high-quality clinical studies are needed in the future.

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