INTRODUCTION: Depression is a common disease worldwide. The main treatment methods currently include medication, psychotherapy, and physical therapy. However, due to limitations in treatment methods, treatment compliance is poor. Participating in various sports is very effective in treating depression. OBJECTIVE: To verify the influence of sports on the condition of depression and on the effect of its clinical treatment. METHODS: The article selected a total of 60 hospitalized patients with depression who were randomly divided into two groups: an experimental group and a control group. The control group took antidepressant drugs for eight weeks, and the experimental group took the drugs with the supplementary practice of sports. The two groups of patients were tested for serum beta-endorphin (beta-EP) levels before and after treatment, and HAMD scores were performed. RESULTS: The scores and serum beta-endorphin (beta-EP) levels of the two groups of patients were different, showing that effect of the treatment was better in the experimental group. CONCLUSION: Physical exercise therapy can mobilize the enthusiasm of patients with depression. This treatment plan increases treatment efficiency and is suitable for long-term clinical promotion and application. Level of evidence II; Therapeutic studies-investigation of treatment results.

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