INTRODUCTION: Interest has recently frown in the use of exercise in managing hypothyroidism associated impairments. The objective of this research was to assess and contrast the effects of aerobic and resistance exercise regimens, and a combination of both, on depressive symptoms and sleep quality in women with managed hypothyroidism. MATERIAL AND METHODS: A total of sixty women, aged 35 to 45 years, with controlled hypothyroidism associated with depression, and sleep problems were randomly assigned to four equally-sized groups: aerobic exercise (AE), resistance exercise (RE), combined AE/RE, and a control group. They engaged in low to moderate intensity workouts, three times a week, during a span of 12 weeks, while also undergoing levothyroxine therapy. Outcome measures included depression assessed with the Beck Depression Inventory II (BDI-II) and sleep quality, evaluated using the Pittsburgh Sleep Quality Index (PSQI). RESULTS: The BDI-II and PSQI showed significant improvements in all exercise groups in comparison to the first measurements and the non-exercising group (p < 0.05). Most significantly, the AE/RE group demonstrated greater improvements in both outcomes then the AE and RE groups alone (p < 0.05). CONCLUSIONS: In well-managed hypothyroid women, AE, RE, and combined AE/RE can improve depression and sleep quality. However, combined AE/RE appears to induce the greatest improvements in both measures.

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