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| Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight/obesity: a randomized clinical trial |
| Gil-Cosano JJ, Plaza-Florido A, Gracia-Marco L, Migueles JH, Cadenas-Sanchez C, Olvera-Rojas M, Ubago-Guisado E, Labayen I, Lucia A, Ortega FB |
| Pediatric Obesity 2024 Oct;19(10):e13152 |
| clinical trial |
| 6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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BACKGROUND: We assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity. METHODS: Totally 109 participants (10.1 +/- 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1beta, IL-6, leptin, tumour necrosis factor-alpha and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined. RESULTS: No intervention effect was found for any of the analysed biomarkers (all p >= 0.05). We observed a significant sex by intervention interaction for IL-1beta (p = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1beta levels (mean Z-score difference, 0.66 (95% confidence interval 0.32 to 1.01)) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1beta (ie, >= 0.2 standard deviations) than in the control group (15% versus 85%, p = 0.01). CONCLUSIONS: This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.
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