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Investigating endurance training with ergometer bicycle in changes the plasma levels of chemerin on overweight women
Ashtiani ARA, Galdavi R, Jafari M
Archives of Pharmacy Practice 2021 Jan-Mar;12(1):50-54
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Adipokine chemerin is a pre-inflammation associated with obesity and metabolic syndrome. The present study aimed to investigate the changes in the plasma levels of chemerin of women with overweight and obese during a period of training on a cycle-ergometer. This study was quasi-experimental type and was performed on 22 overweight and obese women (BMI > 25 kg/m2) who were within the age range of 30 to 45 in Zahedan. Subjects were selected targeted and using permuted block randomization was divided into two groups of subjects including training groups and control groups. The training protocol that was performed lasted for 8 weeks (3 sessions per week) by cycling on a cycle-ergometer (60 to 75% heart rate reserve) with a duration of 16 to 30 minutes. Blood samples were collected in two stages before and after the same conditions to measure plasma levels of chemerin. To analyze the results, t-test, ANOVA, covariance, and Kruskal-Wallis analysis were used at a significant level of alpha < 0.05. Intra-group comparisons showed that 8 weeks of aerobic exercise with ergometer bicycle in addition to a significant reduction of obesity-related factors significantly reduced plasma levels of chemerin in training groups (p = 0.002). A significant difference between the changes in plasma levels of chemerin of the studied groups was observed during the inter-group comparison. To reduce the pre-inflammatory factor of chemerin and obesity-related factors in overweight and obese women, training on the cycle-ergometer has been considered as a preventive approach.

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